By J. Fareed (auth.), Dr. Christian Doutremepuich (eds.)
All clinical experts who needs to cope with the potential for thrombosis might be attracted to Anticoagulation. This e-book evaluates anticoagulation methods from numerous issues of view - from present tendencies in Anti-thrombotic medicinal drugs, to remedy of Ischemic Vascular issues; from Anticoagulants in being pregnant, to Anticoagulation within the aged, from the consequences of Anticoagulant remedy at the center, to Anticoagulation in numerous surgeries. Anticoagulation is a source of methods to the administration of this universal clinical problem.
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Additional info for Anticoagulation
O~~; HCII \ (HI, I b) HEPARINS r MW o,dOD 0,000 (121 (1 21 ~ APlTT~~0'000(121/( I 50,/COO / 1 ED 50 I 0,000 (121 /0,001(111 0,000 12 / AX. -0,002(21 I-HEPTE5T 0,001 (21) -O,OOO( 121- AX. -0,021 (12I-BLEED INS J Figure 1: 1a) Dermatans : correlation between effect (ED 50) and physicochemical biological parameters. ant ithrombot ic and in vitro 1b) Heparins: correlation between anti thrombotic effect (ED 50), bleeding and physicochemical and in vitro biological parameters. Between the different parameters the significance of the Spearman correlation and, in brackets, the number of paired observations are indicated.
In addition, a draw back of its usage consists of hemorragic and thrombopenic risks. Heparin is contra- indicated in cases of hemorrhagic diseases, arterial hypertension and hepatic insufficiency. In attempt to palliate these disadvantages, UFH has been replaced by low molecular weight heparin (LMWH). 2 Low molecular weight hepar ins (LMWH) LMWH are obtained from heparin through different ways of depolymerization and fractionation . Their ways molecular weight generally ranges between 4000 and 6000 d.
Despite the fact that these compounds are weak anticoagulants, they are potent inhibitors of the intrinsic pathway for thrombin generation . As antithrombotic agent, OS has been shown to be as effective as heparin, but with a lower risk of bleeding complications. 4 Pentosan Polysulfate Pentosan Polysulfate (PPS) is a synthetic heparinoid used as an antithrombotic. Its molecular weight is about 6000 daltons. It acts principally on factor Xa and inhibits essentially intrinsic coagulation. Its mechanism of action is not well understood.