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Download Animal Models of Movement Disorders: Volume I by Anne E. Rosser (auth.), Emma L. Lane, Stephen B. Dunnett PDF

By Anne E. Rosser (auth.), Emma L. Lane, Stephen B. Dunnett (eds.)

Movement is the way in which that animals have interaction with their surroundings and is lower than the association and intricate keep an eye on of the mind and spinal wire. a number of important worried platforms, together with cortex, basal ganglia, cerebellum, and brainstem, have interaction to supply distinctive motor keep an eye on and integration. harm or illness inside those structures reason profound motor disturbances in guy, that are successfully modeled in animals to strengthen a greater figuring out and therapy of the human . Animal types of flow Disorders introduces various equipment and strategies used to version and determine motor functionality in experimental animals from decrease orders, akin to drosophila and c. elegans, via vertebrate species together with fish, to mammals, reminiscent of rodents and non-human primates. the main complex modern types in every one method are offered at a number of degrees of research from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behaviour. Volume I comprises common equipment of circulate sickness overview in addition to an in depth part on dopamine structures.

Comprehensive and meticulous, Animal versions of circulate Disorders serves as a helpful reference for these learning motor problems by way of overlaying methodologies intimately and supplying the data essential to ponder either the right versions and evaluate instruments which could such a lot informatively solution the foremost experimental concerns within the field.

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Neurobiol Dis 40:93–101. 35. Anichtchik O, Sallinen V, Peitsaro N, Panula P (2006) Distinct structure and activity of 28 M. Sundvik and P. Panula monoamine oxidase in the brain of zebrafish (Danio rerio). J Comp Neurol 498:593–610. 36. Sallinen V, Sundvik M, Reenila I, Peitsaro N, Khrustalyov D, Anichtchik O, Toleikyte G, Kaslin J, Panula P (2009) Hyperserotonergic phenotype after monoamine oxidase inhibition in larval zebrafish. J Neurochem 109:403–415. 37. Anichtchik OV, Kaslin J, Peitsaro N, Scheinin M, Panula P (2004) Neurochemical and behavioural changes in zebrafish Danio rerio after systemic administration of 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

In t-tubules (82) PINK1 (Park6) trMO Diencephalic DA cells (th1) Small eyes, curved tails Enlarged brain ventricles Elevated GSK3b activity Early larval death (77) PINK1 (Park6) spMO Diencephalic DA cells (th1 and th2, DAT) Increased sensitivity to MPTP Decreased swimming following low MPTP (34) PINK1 (Park6) trMO Diencephalic DA cells Increased p53 and Dtp113 Decreased swimming Dispersed th1 neurons in diencephalon Delayed swim bladder devl Craniofacial malformation (34) PINK1 (park6) trMO Diencephalic DA cells (th1) Several morphological defects Dispersed DA neurons Decreased tactile responses (78) DJ1 (Park7) spMO None (th1) Increased SOD1 mRNA Increased p53 mRNA Increased Bax mRNA (74) LRRK2 (Park8) trMO Diencephalic DA cells Lethality Heart edema, reduced brain size (75) LRRK2 (Park8) spMO Diencephalic DA neurons (th1 and DAT) Widespread increased apoptosis Decreased locomotion (75) spMO splicing site targeting MO, trMO translation initiation site targeting MO, DA cells dopamine-producing cells 24 M.

45. Burgess HA, Schoch H, Granato M (2010) Distinct retinal pathways drive spatial orientation behaviors in zebrafish navigation. Curr Biol 20:381–386. 46. Burgess HA, Granato M (2007) Modulation of locomotor activity in larval zebrafish during light adaptation. J Exp Biol 210:2526–2539. 47. Gahtan E, Tanger P, Baier H (2005) Visual prey capture in larval zebrafish is controlled by identified reticulospinal neurons downstream of the tectum. J Neurosci 25:9294–9303. 48. Peitsaro N, Kaslin J, Anichtchik OV, Panula P (2003) Modulation of the histaminergic system and behaviour by alpha-fluoromethylhistidine in zebrafish.

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