By Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)
Basic learn on osteoarthritis has been conducted frequently from the his tological and biochemical facets of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical pressure has been proven to be the imperative consider the initiation of osteoarthritis. even though the precise approach in which mechanical pressure ends up in the complete destruction of cartilage tissue continues to be uncertain, a number of new study equipment have enabled us to realize a deeper knowing of the method of degeneration. In October 1997, we geared up a global symposium titled "Ad vances in Osteoarthritis" in Kobe, with the most subject matters being up-to-date re seek, prognosis, and remedy of osteoarthritis. The complaints of the symposium are provided right here in 5 sections: (1) Mechanical rigidity and reactions of chondrocytes, equivalent to intracellular ion alterations, adjustments within the cytoskeleton, intracellular messenger platforms, liberate of gasoline mediators, and alterations in electromechanical houses of cartilage; (2) practical prognosis of osteoarthritis via MR imaging, and utilizing calpain and collagenase III as new cartilage markers; (3) therapy with a promising easy washout procedure and IL-1RA and MMP antagonists; (4) Cartilage fix via new grafting tech niques; and (5) difficulties following overall joint substitute. We basically desire that the complicated wisdom supplied during this quantity of lawsuits should be worthy to our readers.
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Additional info for Advances in Osteoarthritis
The skillful and efficient technical assistance of Mrs. Elma Sorsa and Ms. Eija Antikainen is gratefully acknowledged. This work was financially supported by grants from the University of Kuopio, the North Savo Fund of the Finnish Cultural Foundation, the Finnish Cultural Foundation, the Academy of Finland, the Sigrid Juselius Foundation, and the Finnish Research Council for Physical Education and Sports, Ministry of Education. References 1. Tammi M, Paukkonen K, Kiviranta I, et al (1987) Joint loading-induced alterations 2.
Heinegard D, Sommarin Y (1987) Proteoglycans: an overview. Methods Enzymol 144:305-319 2. Videman T, Eronen I, Friman C (1981) Experimental osteoarthritis in the rabbit. Acta Orthop Scand 52:11-22 3. Saamanen A-M, Tammi M, Kiviranta I, et al (1988) Running exercise as a modu- 4. 5. 6. 7. lator of proteoglycan matrix in the articular cartilage of young rabbits. Int J Sports Med 9:127-132 Juvelin J, Kiviranta I, Saamanen A-M, et al (1990) Indentation stiffness of canine knee articular cartilage- influence of strenuous joint loading.
In normal articular cartilage, the matrix components undergo a continuous and balanced turnover. Fibrillar collagen is very resistant to proteolytic cleavage and has a very slow turnover rate, while proteoglycans respond more quickly to the chemical and environmental alterations in the tissue. Serum, or growth factors such as insulin-like growth factor (IGF), stimulate proteoglycan synthesis and seem to be necessary for maintenance of the proteoglycan content in cartilage explants in vitro .