By Richard E. Stone (Auth.)
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Ado, transporter. , 1 9 8 0 ) . R e c e n t l y , M i s u m i et al. ( 1990) h a v e c l o n e d a n d s e q u e n c e d t h e c D N A of r a t liver e c t o - 5 ' - n u c l e o t i d a s e . T h e s e a u t h o r s h a v e also c o n f i r m e d t h e e x t r a c e l l u l a r l o c a t i o n of t h e c a t a l y t i c site of this e n z y m e . T h u s , this e n z y m e is inaccessible to c y t o p l a s m i c n u c l e o t i d e s . E c t o - 5 ' n u c l e o t i d a s e in s h e e p b r a i n , chick glial a n d n e u r a l p r e p a r a t i o n s , like e c t o - 5 ' n u c l e o t i d a s e in o t h e r tissues, is i n h i b i t e d b y A D P , A T P a n d b y a , / ?