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By Richard E. Stone (Auth.)

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M . Berne, T . W . Rail and R. Rubio. Martinus Nijhoff, T h e Hague, pp. 4 3 9 - 5 4 . Schultz, V. and Lowenstein, J . M . (1978). J. Biol. Chem. 253, 1938-43. M. (1975). J. Physiol. ) 247, 145-62. C. C. (1990). Biochem. J. 268, 117-22. B. C. (1989). Biochem. J. 262, 2 0 3 - 8 . H. (1985). Ann. Rev. Neurosci. 8, 103-24. , Edwards, M . R . and Luzio, J . P . (1980). Biochem. J. 186, 5 9 - 6 9 . , Ledig, M . and Mandel, P. (1976). J. Neurochem. 27, 7 9 9 - 8 0 5 . 41 P. R. and L o w e n s t e i n J .

1983). Neuropharmacology 22, 1081-6. , Nakamura, S. and K a m e y a m a , M . (1984). J . Neurochem. 42, 1001-7. Nagy, J . I . , Buss, M . E. (1984). Science 224, 1 6 6 - 8 . Nagy, J . I . , Geiger, J . D . E. (1985). Neurosci. Lett. 55, 4 7 - 5 3 . Naito, Y. and Lowenstein, J . M . (1981). Biochemistry 20, 5 1 8 8 - 9 4 . C. (1984). Trends Biochem. Sei. 9, 4 2 - 4 . C. (1988). Biochem. J. 253, 123-30. , Worku, Y. and Meghji, P. ( 1987). In Topics and Perspectives in Adenosine Research, eds E.

Ado, transporter. , 1 9 8 0 ) . R e c e n t l y , M i s u m i et al. ( 1990) h a v e c l o n e d a n d s e q u e n c e d t h e c D N A of r a t liver e c t o - 5 ' - n u c l e o t i d a s e . T h e s e a u t h o r s h a v e also c o n f i r m e d t h e e x t r a c e l l u l a r l o c a t i o n of t h e c a t a l y t i c site of this e n z y m e . T h u s , this e n z y m e is inaccessible to c y t o p l a s m i c n u c l e o t i d e s . E c t o - 5 ' n u c l e o t i d a s e in s h e e p b r a i n , chick glial a n d n e u r a l p r e p a r a t i o n s , like e c t o - 5 ' n u c l e o t i d a s e in o t h e r tissues, is i n h i b i t e d b y A D P , A T P a n d b y a , / ?

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