Mammals

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By William J. Krause

A renewed curiosity is starting to emerge spotting the possibility of marsupials as specified versions for biomedical examine. as a result of their abbreviated interval of intrauterine improvement, marsupials are obtainable types with which to check the early improvement of mammalian organ platforms. The North American opossum (Didelphis virginiana) has bought extra clinical scrutiny than the other marsupial to this point. the aim of volumes I and II is twofold. the 1st target is to attract jointly and in brief summarize the morphologal occasions and aiding quantitative facts fascinated about the histogenesis/organogenesis of a few of the organ platforms during this specific species. the second one aim is to supply an creation into the literature with reference to the biology of Didelphis virginiana and to assemble jointly quite a few reviews that experience serious about this species. quantity I summarizes gametes and fertilization, blastocyst formation and early organogenesis, fetal membranes and placentation, parturition and migration to the pouch, common postnatal progress and improvement, and histogenesis/organogenesis of the integument, musculoskeletal process, cardiovascular procedure, blood and blood forming organs, lymphatic organs, anxious procedure, eye, and ear. quantity II summarizes the histogenesis/organogenesis of the respiration approach, digestive method, urinary method, male reproductive procedure, lady reproductive approach, and classical endocrine system.

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Additional info for A Review of Histogenesis/Organogenesis in the Developing North American Opossum (Didelphis virginiana)

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The liver during the latter part of the postnatal period (50-85 days postnatal) also undergoes major metabolic and physiological changes. An increase in the activities of the isoenzymes, lactate and malate dehydrogenase (Renfree and Fox 1975), as well as hepatic cytochromes (Neims et al. 1976), suggests that the development of metabolism, and perhaps other tissue functions, occurs at about this time. The gall bladder and common bile duct have been studied in the adult opossum (Dubois and Hunt 1932a,b); developmentally the anlage of the gall bladder has been described (McCrady 1938).

1978). Islets are poorly defined and the exocrine tubules end as solid clusters of undifferentiated cells, among which scattered endocrine cells and pro acinar cells are observed. Cells that comprise the remainder of the exocrine tubules are smaller than proacinar cells and range from simple squamous to simple columnar. Regions of stratification also occur in the epithelium of the exocrine tubules and exhibit numerous mitotic figures. Such regions represent peritubular buds that characterize the pancreas through the first postnatal weeks, and will eventually differentiate into endocrine and exocrine components of the pancreas.

07 Duodenum Small intestine Colon epithelium ~ntil about the 75th postnatal day and are concentrated primarily in the distal segments of the small intestine (Table 32). Unlike other enteroendocrine cell types, they follow a distal to proximal progression in their distribution as they increase in number in the small intestine with age (Krause et al. 1989b). Neurotensin-immunoreactive cells, although observed in the proximal colon of the newborn opossum, do not form a significant population until 75 days postnatal, and then are distributed throughout the colon.

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